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Accueil > Recherche > Laboratoires > Chimie physique

LABORATOIRE DE CHIMIE PHYSIQUE ET MINERALE

Directeur : Professeur Jacques Métin

Adresse :   Faculté de Pharmacie
                  28 place Henri Dunant - BP 38
                  63001 Clermont-Ferrand

Tél. -Phone :   +33 (0)4 73 17 80 06
Fax :                +33 (0)4 73 17 80 01
Courriel :           jacques.metin@udamail.fr


Personnels :

Jacques Métin, PU, jacques.metin@udamail.fr
Philippe Auzeloux, MCU, philippe.auzeloux@udamail.fr
Vincent Gaumet, MCU, vincent.gaumet@udamail.fr
Magali Vivier, MCU, magali.vivier@udamail.fr

Fernand Leal, IGE, fernand.leal@udamail.fr
Ariane BAUFOND, AdT, ariane.baufond@udamail.fr



Activités d'enseignement

PACES

UE 1 : CM 21h ; ED   8h
UE 3 : CM   6h ; ED   2h

APEMK

Chimie générale : CM 27h ; ED 10h

L1 Sciences pour la santé

Chimie physique : CM 20h ; ED 18h ; TP 12h

Pharmacie DFGSP2

UE 1 : Apprentissage des techniques et gestes de base ; TP 6h
UE 5 : Voies d'accès aux substances actives médicamenteuses ; CM 2h ; TP 3h
UE 7 : Sciences analytiques ; CM 10h ; ED 2h ; TP 3h
UE librement choisie : CM 14h ; ED 3h ; TP 3h

D.U. préparatoire aux parcours Nutrition et Pharmacologie de la Licence STS pour étudiants étrangers

non enseigné en 2014-2015

UM : Conception et structure des molécules d'intérêt thérapeutique ; CM 10h ; TP 2h

UM : Biodisponibilité des médicaments ; CM 2h ; ED 6h

Stage Recherche M1 "étudiants en santé" : 8 semaines de stage



Activités de recherche
 

Le laboratoire est rattaché à l'équipe de recherche UMR INSERM-Université d'Auvergne 990 "Imagerie Moléculaire et Thérapie Vectorisée" (Responsable : Pr Jean-Michel Chezal)
 

Références bibliographiques


Y. PERROT, F. DEGOUL, P. AUZELOUX, M. BONNET, F CACHIN, J-M. CHEZAL D. DONNARIEIX, P. LABARRE, N. MOINS, J. PAPON, L. RBAH-VIDAL, A. VIDAL, E. MIOT-NOIRAULT, L. MAIGNE
Internal dosimetry through GATE simulations of preclinical radiotherapy using melanin-targeting ligand
Phys. Med. Biol. 2014, 9 (9), 2183-2198.

E. MIOT-NOIRAULT, A. VIDAL, C. PEYRODE, C. MERLE, P. AUZELOUX, B. BOUCHON, V. WEBER, S. BESSE, F. DEGOUL, J.M. CHEZAL
Stratégie prometteuse pour le management du chondrosarcome : vectorisation de radio-isotopes et d’agents de chimiothérapie vers les protéoglycanes
Médecine Nucléaire. 2014, 38(3), 138.

V. GAUMET, C. DENIS, F. LEAL, M. MADESCLAIRE, V.P. ZAITSEV
[(2R,3R)-3-(4-Nitrophenyl)aziridin-2-yl]methanol monohydrate
Acta Cryst., 2013, E69, o927.

V. GAUMET, C. DENIS, M. MADESCLAIRE, V.P. ZAITSEV
(4S)-4-[(R)-Chloro(4-nitrophenyl)methyl]-1,3-oxazolidin-2-one
Acta Cryst., 2013, E69, o783.

E.M.F. BILLAUD, L. RBAH-VIDAL, A. VIDAL, S. BESSE, S. TARRIT, S. ASKIENAZY, A. MAISONIAL, N. MOINS, J.C. MADELMONT, E. MIOT-NOIRAULT, J.M. CHEZAL, P. AUZELOUX
Synthesis, radiofluorination and in vivo evaluation of novel fluorinated and iodinated radiotracers for PET imaging and targeted radionuclide therapy of melanoma.
J. Med. Chem. 2013, 56 (21), 8455–8467.

C. KIEDA, B. EL HAFNY-RAHBI, G. COLLET, N. LAMERANT-FAYEL, C. GRILLON, A. GUICHARD, J. DULAK, A. JOZKOWICZ, J. KOTLINOWSKI, K. C. FYLAKTAKIDOU, A. VIDAL, P. AUZELOUX, E. MIOT-NOIRAULT, J.C. BELOEIL, J.M. LEHN, C. NICOLAU
Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment
Journal of Molecular Medicine. 2013, 91 (7), 883-899.

A. MAISONIAL, E.M.F. BILLAUD, S. BESSE, L. RBAH-VIDAL, J. PAPON, L. AUDIN, M. BAYLE, M-J. GALMIER, S. TARRIT, M. BOREL, S. ASKIENAZY, J.C. MADELMONT, N. MOINS, P. AUZELOUX, E. MIOT-NOIRAULT, J.M. CHEZAL
Synthesis, radioiodination and in vivo screening of novel potent iodinated and fluorinated radiotracers as melanoma imaging and therapeutic probes.
European Journal of Medicinal Chemistry. 2013, 63, 840-853.

L. RBAH-VIDAL, A. VIDAL, S. BESSE, F. CACHIN, M. BONNET, L. AUDIN, S. ASKIENAZY, F. DOLLÉ, F. DEGOUL, E. MIOT-NOIRAULT, N. MOINS, P. AUZELOUX, J.M. CHEZAL.
Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer.
Eur J Nucl Med Mol Imaging. 2012, 39, 1449-1461.

K. ALOMAR, V. GAUMET, M. ALLAIN, G. BOUET, A. LANDREAU
Synthesis, crystal structure, characterization, antifungal activity of 3-thiophene aldehyde semicarbazone (3STCH), 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH2) and their nickel(II) complexes.
Journal of Inorganic Biochemistry 2012, 115, 36-43.

K. ALOMAR, V. GAUMET, M. ALLAIN, P. RICHOMME, G. BOUET
Complexes of thiophene -2,3-dicarboxaldehyde bis(oxime) (2,3BTCOH2) with nickel(II) and copper(II): synthesis, characterization, crystal structure of 2,3BTCOH2. Rearrangement reaction with nickel(II) bromide.
Inorganica Chimica Acta 2012, 392, 433-439.

N. MASURIER, R. ARUTA, V. GAUMET, S. DENOYELLE, E. MOREAU, V. LISOWSKI, J. MARTINEZ, L.T. MAILLARD
Selective C-acylation of 2-amino-imidazo[1,2-a]pyridine: Application to the synthesis of imidazopyridine-fused [1,3]diazepinones
J. Org. Chem. 2012, 77, 3679-3685.

E. MIOT-NOIRAULT, J. GUICHEUX, A. VIDAL, O;GAUTHIER, P. AUZELOUX, J LESOEUR, F. CACHIN, S. ASKIENAZY, J.M. CHEZAL, C. VINATIER.
In Vivo experimental imaging of osteochondral defect and healing using 99mTc- NTP 15-5 radiotrace
Eur J Nucl Med Mol Imaging, 2012, 39, 1169-1172.

E. MIOT-NOIRAULT, A. VIDAL, P. AUZELOUX, C. PEYRODE, J.C. MADELMONT, J.M. CHEZAL
In vivo scintigraphic imaging of proteoglycans
Methods Mol Biol, 2012, 836, 183-198.

C. PEYRODE, V. WEBER, E. DAVID, A. VIDAL, P. AUZELOUX, Y. COMMUNAL, M.M. DAUPLAT, S. BESSE, F. GOUIN, D. HEYMANN, J.M. CHEZAL, F. REDINI, E. MIOT-NOIRAULT
Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma : in vitro and in vivo preclinical studies.
Investigational new drugs, 2012, 30, 1782-1790.

M. VIVIER, M. RAPP, M.J. GALMIER, A.-S. JAROUSSE, E. MIOT-NOIRAULT, F. LEAL, V. WEBER, J. METIN, J. SAUZIERE, J.M. CHEZAL, J.C. MADELMONT
New aldehyde and vinylsulfone proteasome inhibitors for targeted melanoma therapy.
Eur. J. Med. Chem., 2011, 46, 5705-5710.

A. MAISONIAL, B. KUHNAST, J. PAPON, R. BOISGARD, M. BAYLE, A. VIDAL, P. AUZELOUX, L. RBAH, M. BONNET-DUQUENNOY, E. MIOT-NOIRAULT, M.J. GALMIER, M. BOREL, S. ASKIENAZY, F. DOLLE, B. TAVITIAN, J.C. MADELMONT, N. MOINS, J.M. CHEZAL
Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma : new multimodal fluorinated and iodinated radiotracers.
J. Med. Chem., 2011, 54, 2745-2766.

F. CACHIN, S. BOISGARD, A. VIDAL, M. FILAIRE, P. AUZELOUX, D. CULOT, S. ASKIENAZY, J.C. MADELMONT, J.M. CHEZAL, E. MIOT-NOIRAULT
First ex vivo study demonstrating that 99mTc-NTP 15-5 radiotracer binds to human articular cartilage.
Eur. J. Nucl. Med. Mol. Imaging, 2011, 38, 2077-2082.

C. PEYRODE, F. GOUIN, A. VIDAL, P. AUZELOUX, S. BESSE, M.M. DAUPLAT, S. ASKIENAZY, D. HEYMANN, J.M. CHEZAL, F. REDINI, E. MIOT-NOIRAULT
A "Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model.
Sarcoma, 2011, Article ID 691608.

A. MAISONIAL, B. KUHNAST, J. PAPON, R. BOISGARD, M. BAYLE, A. VIDAL, P. AUZELOUX, L. RBAH, M. BONNET-DUQUENNOY, E. MIOT-NOIRAULT, M.J. GALMIER, M. BOREL, S. ASKIENAZY, F. DOLLÉ, B. TAVITIAN, J.C. MADELMONT, N. MOINS, J.M. CHEZAL
Single Photon Emission Computed Tomography/Positron Emission Tomography Imaging and Targeted Radionuclide Therapy of Melanoma:NewMultimodal Fluorinated and Iodinated Radiotracers
J. Med. Chem., 2011; 54, 2745-66.

V. GAUMET, E. MOREAU, A. TALEB, F. LEAL, J. NEYTS, J. PAESHUYSE, C. LARTIGUE, O. CHAVIGNON, A. GUEIFFIER, J.C. TEULADE, J. METIN, J.M. CHEZAL
Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives.
Tetrahedron Letters, 2010, 51, 6082-6085.

A. VIDAL, P. AUZELOUX, A. MAISONIAL, L. RBAH, M. BAYLE, J.-B. DELOYE, S. ASKIENAZY, E. MIOT-NOIRAULT, N. MOINS, J.M. CHEZAL
Radiotraceurs multimodaux : marquage par le fluor-18 d'une molécule iodée et fluorée destinée au diagnostique et à la thérapie du mélanome malin.
Bull. Cancer, 2010, 97, 821.

M. MADESCLAIRE, V. GAUMET, V. WEBER, J. METIN, V.P. ZAITSEV, YU V. ZAITSEVA
Crystal structure investigation of (4S,5S)-4-[dichloroacetoxy)methyl]-5-(4-nitrophenyl)-2-oxazolidinory
Chemistry of Heteroxyclic Compounds, 2010, 46(6), 721-725.

J.M. CHEZAL, J. PAESHUYSE, V. GAUMET, D. CANITROT, A. MAISONIAL, C. LARTIGUE, A. GUEIFFIER, E. MOREAU, J.C. TEULADE, O. CHAVIGNON, J. NEYTS
Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus.
Eur. J. Med. Chem., 2010, 45, 2044-2047.

E. MIOT-NOIRAULT, A. VIDAL, F. GOUIN, P. AUZELOUX, N. MOINS, J. MAUBLANT, S. ASKIENAZY, D. HEYMANN, F. REDINI, J.M. CHEZAL
Experimental validation of 99mTc-NTP 15-5 as a SPECT radiotracer for in vivo assessment of degenerative and tumoral pathologies of cartilage.
Eur. J. Nucl. Med. Mol. Imaging, 2009, 36 Suppl 2, S241 : OP 423.

F. CACHIN, J.M. CHEZAL, E. MIOT-NOIRAULT, N. MOINS, P. AUZELOUX, A. VIDAL, M. BONNET-DUQUENNOY, S. BOISGARD, M. FILAIRE, D. MESTAS, A. KELLY,C. MERLIN, F. REDINI, M. D'INCAN, J.C. MADELMONT, A. VEYRE, J. MAUBLANT.
Nouveaux traceurs TEMP : exemple des traceurs des protéoglycanes et de la mélanine.
Médecine Nucléaire 2009, 33: 161-169.

V. GAUMET, V. WEBER, V.P. ZAITSEV, M. MADESCLAIRE
(2R, 3S)-2-ammonio-3-hydroxy-3-(4-nitrophenyl)propanoic acid chloride monohydrate.
Acta Cryst. 2008, E64, o1003-o1004.

N. MASURIER, E. MOREAU, C. LARTIGUE, V. GAUMET, J.M. CHEZAL, A. HEITZ, J.C. TEULADE, O. CHAVIGNON
New opportunities with the Duff reaction.
J. Org. Chem., 2008, 73, 5989-5992.

M. VIVIER, M. RAPP, J. PAPON, P. LABARRE, M.J. GALMIER, J. SAUZIERE, J.C. MADELMONT
Synthesis, radiosynthesis, and biological evaluation of new proteasome inhibitors in a tumor targeting approach.
J. Med. Chem. 2008, 51, 1043-7.

N. DESBOIS, M. GARDETTE, J. PAPON, P. LABARRE, A. MAISONIAL, P. AUZELOUX, C. LARTIGUE, B. BOUCHON, E. DEBITON, Y. BLACHE, O. CHAVIGNON, J.C. TEULADE, J. MAUBLANT, J.C. MADELMONT, N. MOINS, J.M. CHEZAL
Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.
Bioorgan. Med. Chem. 2008, 16, 7671-7690.

E. MIOT-NOIRAULT, A. VIDAL, P. AUZELOUX, J.C. MADELMONT, J. MAUBLANT, N. MOINS.
First In Vivo SPECT Imaging of Mouse Femorotibial Cartilage Using 99mTc-NTP 15-5
Molecular Imaging 2008, 7 (6): 263-271.

R. AFFANI, P. AUZELOUX, J.C. MADELMONT, D. DUGAT
Macrocyclic 14-membered ring diketal diamines: synthesis, conformational analysis and 99mTc radiolabeling evaluation.
Eur. J. Org. Chem., 2008, 12, 2039-2048.

J. NEYTS, J. PAESHUYSE, O. CHAVIGNON, J.M. CHEZAL, V. GAUMET, A. GUEIFFIER, J.C. TEULADE
Imidazo[1,2-a]pyrrolo[3,2-c]pyridine compounds useful as pestivirus inhibitors.
BREVET
International Application Number : PCT/BE2007/000127
International Publication Number : WO 2008/070937
International Publication Date : 19 june 2008
International Patent Classification : C07D471/04(2006.1) A61K 31/4355(2006.1

M. MADESCLAIRE, P. COUDERT, V. GAUMET, V.P. ZAITSEV, YU.V. ZAITSEVA.
X-Ray cristallography of (1R,2R,4S,5S,8S)-2,8-bis(4-chlorophenyl)-4-(4-nitrophenyl)-1-aza-3,7-dioxabicyclo[3,3,0]octanes.
Chemistry of Heterocyclic Compounds, 42, N°6, 813-817, 2006

M. MADESCLAIRE, P. COUDERT, V. GAUMET, V.P. ZAITSEV, YU.V. ZAITSEVA.
Diastereoselective reaction of (1S,2S)-2-amino-1-(4-nitrophenyl)-1,3-propanediol with aromatic aldehydes. Synthesis of (1R,2R,4S,5S,8S)-2,8-diaryl-4-(4-nitrophenyl)-1-aza-3,7-dioxabicyclo[3,3,0]octanes.
Chemistry of Heterocyclic Compounds, 42, N°5, 665-670, 2006

M. VIVIER, A.S. JARROUSSE, B. BOUCHON, M.J. GALMIER, P. AUZELOUX, J. SAUZIERES, J.C. MADELMONT
Preliminary Studies of New Proteasome Inhibitors in Tumor Targeting Approach : Synthesis and In Vitro Cytotoxicity.
J. Med. Chem., 48, 6731-40, 2005

M. VIVIER, A.S. JARROUSSE, P. AUZELOUX, J.C. MADELMONT
Preliminary studies of pharmacomodulated proteasome inhibitors as antitumor agents: synthesis and evaluation of in vitro cytotoxicity.
6th Worshop on proteasomes, avril 2005.

J.M. CHEZAL, E. MOREAU, O. CHAVIGNON, V. GAUMET, J. METIN, Y. BLACHE, A. DIEZ, X. FRADERA, J. LUQUE, J.C. TEULADE.
Aminoimidazo[1,2a]pyridines: regioselective synthesis of subtituted imidazonaphthyridines, azacarbolines and cyclazines.
Tetrahedron, 58 , 295-307, 2002.

S. CEARD, D. ROCHE, V. GAUMET, D. GARDETTE, J. METIN, M. MADESCLAIRE.
Stereoselective synthesis of (E)-N,N-diethyl-3-(imidazo[1,2-a]pyrid-2-yl)-2-(phenylsulfonyl)propenamide.
Journal of Molecular Structure, 608, 27-33, 2002.

C. DECHAMBRE, J. M. CHEZAL, E. MOREAU, F. ESTOUR, B. COMBOURIEU, G. GRASSY, A. GUEIFFIER, C. ENGUEHARD, V. GAUMET, O. CHAVIGNON, J.C. TEULADE.
Efficient synthesis of imiddazopyridodiazepines from peri annulation in imidazo [1,2-a]pyridine.
Tetrahedron Letters, 43, 9119-9123, 2002.

F. TURPIN, F. MASRI, F. RICHE, E. BERTHOMMIER, P. EMOND, M. VIDAL, P. AUZELOUX, C. LOC'H, N. NEUQUELMAN, L. MAUCLAIRE
Synthesis of two novel oxocyclam-binding technetium complexes containing an analogue of cocaine.
J. Label. Compd. Radiopharm. , 45: 379-393, 2002

P. AUZELOUX, J. PAPON, R. PASQUALINI, J.C. MADELMONT
Synthesis and Biodistribution of a New Oxo-technetium-99m Bis(aminothiol) Complex as a Potential Melanoma Tracer.
J. Med. Chem., 44, 1116-21, 2001.

F. ESTOUR, S. REZEL, D. FRAISSE, J. METIN, V. GAUMET, C. LARTIGUE, G. MISCORIAI, A. GUEIFFIER, Y. BLACHE, J.C. TEULADE, O. CHAVIGNON.
Regioselectivity of 1,3-dipolar cycloaddition of 3-oxidopyridinium betaines to olefins and stereoselective synthesis of 6-alkyloxy-5-oxa-9-azatricyclo[5.2.1.0]decan-2-one derivatives.
Heterocycles, Vol 50 (2) 929-945, 1999.

M. BEBOT, P. COUDERT, F. LEAL, J. METIN, V. GAUMET, S. MAVEL, C. RUBAT, J. COUQUELET.
Reaction of 4-bromobenzyl-3-methyl-1, 2-oxazin-6-ones with primary aliphatic amines. Synthesis and structural determination of new oxazine and isoxazole derivates.
Heterocycles, 48 (3), 451-459, 1998.

S. CEARD, V. GAUMET, D. ROCHE, J. METIN, M. MADESCLAIRE.
N,N-Diethylphenylsulfonylacetamide.
Acta Cryst. , C54(12), 1998.

D. AVIGNANT, E. LARGEAU, V. GAUMET, P. DUGAT, M. EL-GHOZZI
Recent progress in tetravalent terbiium chemisty.
Journal of Alloys and Compounds, 1998, 275-277, 1-5.

E. LARGEAU, M. EL-GHOZZI, J. METIN, D. AVIGNANT.
Beta-BaTbF6.
Acta Cryst., C53, 530, 1997.

J.M. CHEZAL, G. DELMAS, S. MAVEL, H. ELAKMAOUI, J. METIN, A. DIEZ, Y. BLACHE, A. GUEIFFIER, M. RUBIRALTA, J.C. TEULADE, O. CHAVIGNON.
Solid-supported heterocumulenes: Preparation and Crystal Structure of Aza-Aplysinopsin.
J. Org. Chem., 62, 4085, 1997.

V. GAUMET, D. AVIGNANT
Caesium Pentafluoroterbate , CsTbF5
Acta Cryst ., 1997, C53, 1176-1178.

E. LARGEAU, V. GAUMET, M. EL-GHOZZI, D. AVIGNANT, J.C. COUSSEINS
Synthesis and single-crystal structural study of an original low-temperature form α of BaTbF6.
J. Mat. Chem., 1997, 7, (9), 1881-1885.

V. GAUMET, E. LARGEAU, D. AVIGNANT
Crystal structure of KTbF5 and early crystal-chemical data from single-crystal works for eight-coordinated Tb4+ ion.
Eur. J. Solid State Inorg. Chem., 1997, 34, 1075-1084.

V. GAUMET, M. EL-GHOZZI, J.C. COUSSEINS, D. AVIGNANT
On the averaged crystal structure of the TlZn1,5+xZr1,5-xF10-2x (x ≈ 0.15) non-stoichiometric phase.
Eur. J. Solid State Inorg. Chem., 1997, 34, 343-354.

V. GAUMET, M. EL-GHOZZI, D. AVIGNANT
Crystal structure of KZrF5
Eur. J. Solid State Inorg. Chem., 1997, 34, 283-293.

V. GAUMET, M. EL-GHOZZI, D. AVIGNANT
The crystal structure of Tl3ThF7 : a case of stereochemical activity of TT+ lone pair in fluorides.
Eur. J. Solid State Inorg. Chem., 1995, 32, 893-905.

V. GAUMET, C. LATOUCHE, D. AVIGNANT, J. DUPUIS
Enhancement of cationic conductivity in some heptafluorozirconates due to a paddle-wheel mechanism.
Solid State Ionics, 1994, 74, 29-35.
 


dernière mise à jour le 12/02/2015 par Jacques Métin

Clermont Université Université Clermont Auvergne